The primary treatment regimen for Helicobacter pylori infection for Kuwaitis does not contain metronidazole, but that for expatriates does. There is also increasing failure of antimicrobial therapy.
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The epidemiology of Clostridium difficile infection (CDI) among oncology inpatients is poorly understood. In multivariate analysis we identified age, history of CDI, and prior receipt of cephalosporins, β-lactam/β-lactamase inhibitors, metronidazole, and blood transfusion as risk factors associated with CDI. Reducing broad-spectrum antibiotic use, particularly among older patients and those with a CDI history and recent blood transfusions, may decrease CDI risk in this population.
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These results show that LAN administration and the concomitant use of antimicrobial drugs during HP eradication therapy do not seem to be associated with significant modifications in liver CYP-450 activity.
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Studies were excluded if they: 1) included data from a previously published article; 2) included daily rinsing with chlorhexidine (CHX); or 3) had unclear descriptions of randomization procedures, examiner masking, or concomitant therapies.
Polymicrobial infections are concomitant or successive infections caused by two or more microorganisms at the same site. The most common types of these infections include orofacial, gastro-intestinal, pelvic (PID) infections, solid organ abscesses (brain, liver, lungs), chronic infections (sinusitis, mastoiditis), skin and soft tissue infections ("diabetic foot", cellulitis, necrotic fasciitis), sepsis.
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We compared cultures taken at 23 to 26 weeks of gestation with cultures taken at delivery from women enrolled in the Vaginal Infections and Preterm Birth study to analyze the association of changes in the vaginal flora with preterm birth.
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To study whether the eradication of H. pylori in patients on long-term non-steroidal anti-inflammatory drug therapy prevents the development of ulcers.
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The efflux pump gene hefA plays an important role in multidrug resistance of H pylori.
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The objective of this study was to determine the antimicrobial susceptibility of anaerobic bacteria from the intestinal microflora of healthy children who had not been treated with antimicrobial agents since birth or at 1, 3, 6, 12, 18 and 24 months of age, as well as from children of the same ages treated with the most commonly used antimicrobial agents in Nicaragua. A total of 947 Bacteroides and 745 Clostridium strains were isolated from 67 healthy and 94 antimicrobial-treated children. The minimal inhibitory concentrations of ampicillin, cefoxitin, imipenem, clindamycin, metronidazole and chloramphenicol were determined by the agar dilution method. Detection of ss-lactamase was made by the nitrocefin assay. No bacterial strains resistant to imipenem, clindamycin, metronidazole or chloramphenicol were found. The susceptibility of Bacteroides species to ampicillin and cefoxitin isolated from antimicrobial-treated children decreased progressively as the children reached 24 months of age, from 88% to 78% and from 94% to 81%, respectively. All the Bacteroides strains isolated from the healthy children were 100% susceptible to cefoxitin when they were <=12 months and 92% susceptible after this age; the susceptibility of Bacteroides strains to ampicillin in these children was from 91% at 1 month to 86% at 24 months of age. All Clostridium strains were susceptible to ampicillin and cefoxitin. The ss-lactamase production was seen only in Bacteroides species. These data indicate that a rational use of antimicrobial agents is needed to avoid the development of resistance in anaerobic bacteria.
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The design and construction of a highly selective voltammetric sensor for metronidazole by using a molecularly imprinted polymer (MIP) as recognition element were introduced. A metronidazole selective MIP and a nonimprinted polymer (NIP) were synthesized and then incorporated in the carbon paste electrodes (CPEs). The sensor was applied for metronidazole determination using cathodic stripping voltammetric method. The MIP-CP electrode showed very high recognition ability in comparison to NIP-CPE. Some parameters affecting the sensor response were optimized and then the calibration curve was plotted. Two dynamic linear ranges of 5.64 × 10(-5) to 2.63 × 10(-3) mg L(-1) and 2.63 × 10(-3) to 7.69 × 10(-2) mg L(-1) were obtained. The detection limit of the sensor was calculated as 3.59 × 10(-5) mg L(-1). This sensor was used successfully for metronidazole determination in biological fluids.