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Levoxa (Levaquin)
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Levoxa

Levoxa is used to treat a variety of bacterial infections. This medication belongs to a class of drugs known as quinolone antibiotics. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

Other names for this medication:
Cravit, Cravox, Elequine, Farlev, Glevo, Leflox, Levaquin, Levobact, Levocin, Levoday, Levoflox, Levofloxacin, Levofloxacina, Levofloxacino, Levomac, Levomax, Levox, Levoxacin, Levoxin, Levozine, Loxin, Loxof, Novacilina, Oftaquix, Proxime, Recamicina, Tamiram, Tavanic, Truxa, Ultraquin, Uniflox, Voxin

Similar Products:
Doxycycline, Monodox, Microdox, Periostat

 

Also known as:  Levaquin.

Description

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Levoxa and other antibacterial drugs, Levoxa should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Levoxa Tablets/Injection and Oral Solution are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed in this section. Levoxa Injection is indicated when intravenous administration offers a route of administration advantageous to the patient (e.g., patient cannot tolerate an oral dosage form).

Dosage

The usual dose of Levoxa Tablets or Oral Solution is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection and described in Table 1. The usual dose of Levoxa Injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours.

Overdose

Overdose of the drug should be strictly avoided and if anyone has accidentally taken the overdose of the drug, then the victim should be provided with emergency medical help. Overdose victim can also consult to their local poison helpline. Some of the overdose symptoms include loss of coordination, drooping eyelids, weakness, decreased activity, trouble breathing, sweating, tremors, or seizure.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep in a tightly closed container. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Levoxa are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Risk of tendinitis and tendon rupture is increased. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroids, and in patients with kidney, heart and lung transplants. Discontinue if pain or inflammation in a tendon occurs.

Anaphylactic reactions and allergic skin reactions, serious, occasionally fatal, may occur after first dose.

Hematologic (including agranulocytosis, thrombocytopenia), and renal toxicities may occur after multiple doses.

Hepatotoxicity: Severe, and sometimes fatal, hepatoxicity has been reported. Discontinue immediately if signs and symptoms of hepatitis occur.

Central nervous system effects, including convulsions, anxiety, confusion, depression, and insomnia may occur after the first dose. Use with caution in patients with known or suspected disorders that may predispose them to seizures or lower the seizure threshold.

Clostridium difficile-associated colitis: evaluate if diarrhea occurs.

Peripheral neuropathy: discontinue if symptoms occur in order to prevent irreversibility.

Prolongation of the QT interval and isolated cases of torsade de pointes have been reported. Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval.

levoxa 500 mg ulotka

Acute diarrhea is a common disease worldwide and in Israel, a Mediterranean country. Acute bacterial gastroenteritis (ABGE) is the leading cause of severe diarrhea in Israel in summer and early autumn. Although there are some reports showing some benefit from empiric antibiotic therapy in acute gastroenteritis, most are old reports using nondefinitive diagnostic criteria and using 5-day antibiotic regimens.

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Minimum inhibitory concentrations (MICs), descriptive statistics, antibiotic susceptibility, potency, and statistical analysis.

levoxa 500 mg filmtabletta

Imipenem, levofloxacin or saline were administered to rats with caerulein induced pancreatitis. Twenty-four hours later serum amylase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and NO levels, pancreatic interstitial inflammation, acinar cell necrosis, acinar cell vacuolisation, peripancreatic fat necrosis; spotty necrosis, focal inflammation of liver and inflammatory processes in the lungs were assessed.

levoxa 500 mg tablets

The in vitro activity of clinafloxacin was studied in comparison with ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, sparfloxacin and trovafloxacin against Acinetobacter baumannii clinical isolates. Clinafloxacin showed a MIC(90) of 4 mg/L, whereas the remaining quinolones showed a MIC(90) equal to or higher than 16 mg/L. MIC(50) determination in the presence of reserpine resulted in a two-fold decrease, except for trovafloxacin, which decreased four-fold, and for moxifloxacin and nalidixic acid, which did not change. The effect of reserpine was most pronounced among strains with a low level of resistance to quinolones. The MIC of clinafloxacin for strains with no mutation in either gyrA or parC genes ranged from 0.008 to 0.25 mg/L. In strains with a single mutation at amino acid codon Ser83 of the gyrA gene, the MIC of clinafloxacin ranged from 0.12 to 1 mg/L, whereas strains with a double mutation, one in the gyrA gene and another in the parC gene, showed a range of MIC of clinafloxacin from 1 to 8 mg/L. Therefore, clinafloxacin shows good activity against strains carrying a single mutation in the gyrA gene, and hence a second mutation is required for the microorganism to express resistance.

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Levofloxacin has been widely used because of its broad spectrum and excellent penetration of the prostate. But levofloxacin-resistant Escherichia coli (E.coli) has been reported all over the world. We analyzed the annual levofloxacin resistance of E. coli and its risk factors.

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Patients treated for NF from January 2004 to February 2006 were identified by review of pathology records and diagnostic codes, and their medical records were reviewed. Isolates of MRSA from monomicrobial NF underwent testing for the PVL gene and pulsed-field gel electrophoresis to determine relatedness to CA-MRSA strains.

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The formulation was evaluated for physicochemical characteristics, in vitro drug release. Ocular retention studies were carried out by Gamma scintigraphy. Time activity curve was plotted between marketed formulation and developed formulation for comparing drug drainage from the eye with time. Ocular tolerance test was performed by handheld infra-red camera.

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The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease.

levoxa antibiotic

Two hundred ten bacterial strains were collected and tested including Staphylococcus aureus (29), Group B ß-haemolytic Streptococcus (10), Streptococcus pneumoniae (15), Enterococcus spp. (16), Haemophilus spp. (15), Escherichia coli (26), Klebsiella spp. (26), Enterobacter spp. (25), Serratia spp. (10), Acinetobacter baumannii (17) and Pseudomonas aeruginosa (21). All strains except P. aeuginosa were susceptible to tigecycline. All gram-positive strains were susceptible to linezolid. Meropenem and piperacillin-tazobactam showed good activity against most organisms tested including P. aeruginosa and Acinetobacter baumannii. Levofloxacin showed 100% activity against K. pneumoniae and 61% activity against E. coli. The activity of 3rd generation cephalosporins against E.coli and K.pneumoniae ranged from 76% to 100%.

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levoxa 250 mg 2015-04-27

Tosufloxacin, a quinolone, showed a broad antibacterial spectrum against gram-positive and gram-negative bacteria including anaerobic bacteria. Tosufloxacin was 4- to 8-fold more active than levofloxacin and ciprofloxacin. The MIC90 of tosufloxacin for clinical Ciprofloxacin Kid Dosage isolates of Bacteroides fragilis, Bacteroides vulgatus, Bacteroides thetaiotaomicron and Peptostreptococcus asaccharolyticus were 0.78, 0.39, 1.56 and 0.39 micrograms/ml, respectively. Morphological observation with the scanning and transmission electron microscope revealed that exposure of B. fragilis ATCC 25285 to tosufloxacin resulted in the formation of filamentous cells with mesosome-like structures. Tosufloxacin also induced the mini-cell resulting from the unusual cell division system and a number of holes in the outer membrane. Tosufloxacin at 4 MIC caused some change in cell wall organization and cell lysis. After exposure of P. asaccharolyticus ATCC 14953 to tosufloxacin, the cells increased considerably in size and the cell wall and cross wall thickening was observed.

levoxa antibiotic dosage 2017-12-02

Eight primary schools over the four Pemba districts were Cefdinir 300 Mg Dosage included in the study.

levoxa dosage 2015-05-14

This retrospective study evaluated trends and association between resistance of Pseudomonas aeruginosa isolated from patients with hospital-acquired infections (HAIs) and hospital antimicrobial usage from 2003 through 2011 in a tertiary care hospital in northeast China. HAI was defined as occurrence of infection after hospital admission, without evidence that infection was present or incubating (≦48 h) on admission. In vitro susceptibilities were determined by disk diffusion test and susceptibility profiles were determined using zone diameter interpretive criteria, as recommended by Clinical and Laboratory Standards Institute (CLSI). Data on usage of various antimicrobial agents, expressed as defined daily dose (DDD) per 1,000 patients-days developed by WHO Anatomical Therapeutical Chemical (ATC)/DDD index 2011, were collected from hospital pharmacy computer database. Most of 747 strains of P. aeruginosa were collected from respiratory samples (201 isolates, 26.9%), blood (179, 24.0%), secretions and pus (145, 19.4%) over the years. Time series analysis demonstrated a significant increase in resistance rates of P. aeruginosa to ticarcillin/clavulanic acid, piperacillin/tazobactam, cefoperazone/sulbactam, piperacillin, imipenem, meropenem, ceftazidime, cefepime, ciprofloxacin, and levofloxacin except aminoglycosides over time in the hospital (P<0.001). The rates of carbapenem-resistant P. aeruginosa (CRPA) isolated from patients with HAIs were 14.3%, 17.1%, 21.1%, 24.6%, 37.0%, 48.8%, 56.4%, 51.2%, and 54.1% over time. A significant increase in usage of anti-pseudomonal carbapenems (P<0.001) was seen. ARIMA models demonstrated that anti-pseudomonal carbapenems usage was strongly correlated with the prevalence of imipenem and meropenem-resistant P. aeruginosa (P<0.001). Increasing of quarterly CRPA was strongly correlated at one time lag with quarterly use of anti-pseudomonal carbapenems (P<0.001). Our data demonstrated positive correlation between anti-pseudomonal antimicrobial usage and P. aeruginosa resistance to several classes of antibiotics, but not all Amoxypen En Alcohol antimicrobial agents in the hospital.

levoxa 500 mg opinie 2016-07-27

This study indicates that vancomycin-resistant enterococci are Augmentin Es Dosing often concomitantly resistant to multiple antibiotics. Quinupristin/dalfopristin was the most active agent tested against E. faecium strains. On the basis of these results quinupristin/dalfopristin could be a therapeutic option for the treatment of vancomycin-resistant E. faecium infections.

levoxa 250 mg cena 2016-08-09

Biofilm is a sessile community of bacterial cells enclosed by a self-secreted extracellular polymeric matrix that exhibit a high recalcitrance towards antibiotics. Inhaled antibiotic nanoparticles with a sustained release capability have emerged as one of the most promising anti-biofilm formulations in the fight against respiratory biofilm infections attributed to their ability to penetrate the biofilm sputum. The present work examines the antibacterial efficacies and physical characteristics of different antibiotic-loaded polymeric nanoparticle formulations. PLGA and PCL nanoparticles prepared by an emulsification-solvent-evaporation method are used as the antibiotic carrier nanoparticles. Fluoroquinolone antibiotics (i.e., ciprofloxacin and levofloxacin) are selected as the antibiotic models due to their proven effectiveness against dormant bacterial cells and their ability to penetrate the biofilm matrix. The antibacterial efficacy against E. coli biofilm cells is examined in a time-kill study in which the effects of biofilm age, antibiotic exposure history, and drug removal are taken into account. Ciprofloxacin-loaded PLGA nanoparticles are Azithromycin 3 Day Dose Pack identified as the most ideal formulation due to their high drug encapsulation efficiency, high antibacterial efficacy at a low dose against biofilm cells and biofilm-derived planktonic cells of E. coli. Moreover, the nanoparticulate suspension can be transformed into micro-scale dry-powder aerosols having aerodynamic characteristics ideal for inhaled delivery.

levoxa antibiotic 2016-06-08

This study compared the clinical efficacy and safety of Clavamox Brand Names high-dose levofloxacin with combined ceftriaxone and azithromycin for the treatment of CAP.

levoxa tab 2015-12-17

In the study species distributions and antimicrobial resistance profiles were determined among riverine Enterococcus spp. Susceptibility of the isolates was tested against: ampicillin, imipenem, teicoplanin, vancomycin, erythromycin, linezolid, fosfomycin, ciprofloxacin, levofloxacin, moxifloxacin, tetracycline, high levels of gentamicin and streptomycin. The enterococci were detected in all of the analyzed water samples, periodically exceeding the mandatory standards of the EU Bathing Water Directive. Isolates were predominantly E. faecium (68.6%) and E. faecalis (21.6%) strains. The remaining isolates belonged to E. casseliflavus/gallinarum (5.2%), E. hirae (3.9%), and E. durans (0.7%). Of enterococci strains, 27% were susceptible to all tested antimicrobial agents and as much as 9% were classified as multiple-antibiotic-resistant (MAR). Resistance to erythromycin was common in all investigated areas (55%), followed by resistance to ciprofloxacin (22%) and tetracycline (14%). The resistance phenotypes related to glycopeptides and high-level aminoglycosides were also observed. Relatively low frequency of ampicillin resistance was found among studied strains, in contrast to the frequent use of this antimicrobial agent in Poland. According to the obtained results the Enterococcus should be regarded Cefuroxime 500 Mg Prospect as an important genus, according to its potential contribution to dissemination of antimicrobial resistance in the water environment.