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Klindan (Cleocin)
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Klindan

Klindan is used for treating serious infections caused by certain bacteria. Klindan is a lincomycin antibiotic. Klindan kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Other names for this medication:
Antirobe, Basocin, Biodaclin, Chloramphenicol, Clendix, Cleocin, Clidan, Climadan, Clinacin, Clinda, Clindacin, Clindacne, Clindagel, Clindahexal, Clindal, Clindamax, Clindamicina, Clindasol, Clindesse, Clindets, Clinium, Clinsol, Clinwas, Cutaclin, Dalacin, Dentomycin, Derma, Dermabel, Evoclin, Klimicin, Klindamicin, Mediklin, Sobelin, Tidact, Ziana, Zindaclin

Similar Products:
Clinda derm, Clindagel, Clindets

 

Also known as:  Cleocin.

Description

Klindan is a prescription medication used to treat bacterial infections of the lungs, skin, blood, bones, joints, female reproductive system, and internal organs.

Klindan belongs to a group of drugs called lincomycin antibiotics. These work by stopping the growth of bacteria.

This medication is available as a vaginal cream, vaginal suppository, oral capsule, and oral liquid.

This medication is also available in injectable forms to be given directly into a vein (IV) or a muscle (IM) by a healthcare professional.

Common side effects of Klindan include nausea, vomiting, joint pain, heartburn, pain when swallowing, and white patches in the mouth.

Dosage

Take Klindan exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take the capsule with a full glass of water to keep it from irritating your throat.

Measure the oral liquid with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Klindan is sometimes given as an injection into a muscle, or injected into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

To make sure this medicine is not causing harmful effects, you may need frequent medical tests during treatment.

If you need surgery, tell the surgeon ahead of time that you are using Klindan.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Klindan will not treat a viral infection such as the flu or a common cold.

Store at room temperature away from moisture and heat. Protect the injectable medicine from high heat.

Do not store the oral liquid in the refrigerator. Throw away any unused oral liquid after 2 weeks.

Overdose

In the event the patient misses a dose of Klindan, the patient should take it as soon as possible. However, if it is almost time for the next scheduled dose, taking another dose of Klindan may cause an overdose which can lead to serious health complications. In this case, the missed dose should be skipped entirely to avoid an overdose potential. If an overdose of Klindan is suspected the patient should seek immediate medical intervention and assessment. An overdose may involve symptoms such as changes in mood or behaviors, thoughts of self harm, suicidal thoughts, seizures, or convulsions.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Klindan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Generic Klindan if you are allergic to Generic Klindan components or to to tartrazine.

Be very careful if you're pregnant or you plan to have a baby, or you are a nursing mother.

Try to be very careful with Generic Klindan if it is given to children younger than 10 years old who have diarrhea or an infection of the stomach or bowel. Elderly patient should use Generic Klindan with caution.

Be sure to use Generic Klindan for the full course of treatment.

Avoid alcohol.

It can be dangerous to stop Generic Klindan taking suddenly.

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This study was performed to elucidate the relationship between antimicrobial use density (AUD) and Clostridium difficile infection (CDI) manifesting as antimicrobial-associated diarrhea (AAD) in hospital wards during a 4-year period. Case definition of CDI was an adult exhibiting AAD with a daily stool frequency of three or more, arising at least 48 hours after ward admission, and fecal samples testing positive for toxin (A and/or B). Metronidazole or vancomycin was orally administered as treatment. AUDs were calculated for a total of 21 antimicrobials in a span of 48 months and nine wards. We included the average value of AUDs, representing two succeeding months of sample submission into the sample information. We also entered data on the 2-year division and intensified contact precaution for statistical analysis. Of a total of 463 cases, 95 (20.5%) were CDI-positive. Multivariate regression analysis showed odds ratios [OR] of 1.739 (95% confidence interval [CI] of 1.050 - 2.881, P = 0.032) and 1.598 (95% CI of 1.006 -2.539, P = 0.047) for clindamycin and piperacillin, respectively in AUD. Thus increased ward AUDs of clindamycin and piperacillin may run the risk of CDI.

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Resistance of MRSA to mupirocin appears to be an emerging problem at the UHWI and must be monitored carefully. There is also significant resistance to commonly used antimicrobial agents and strict adherence to antibiotic policy is required to preserve the usefulness of these agents.

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Pityriasis lichenoides (PL) is a skin condition of unclear etiology that occurs not uncommonly in childhood. It is often classified into the acute form, pityriasis lichenoides et varioliformis acuta (PLEVA), and the chronic form, pityriasis lichenoides chronica (PLC). We performed a comprehensive review of the English-language literature using the PubMed database of all cases of childhood PL reported from 1962 to 2014 and summarized the epidemiology, clinical features, treatment options, and prognosis of this condition in children. The proposed etiologies are discussed, including its association with infectious agents, medications, and immunizations and evidence for PL as a lymphoproliferative disorder. We found an average age of PL onset of 6.5 years, with a slight (61%) male predominance. We also found that PLEVA and PLC tend to occur with equal frequency and that, in many cases, there is clinical and histopathologic overlap between the two phenotypes. When systemic therapy is indicated, we propose that oral erythromycin and narrowband ultraviolet B phototherapy should be first-line treatment options for children with PL since they have been shown to be effective and well tolerated. In most cases, PL follows a benign course with no greater risk of cutaneous T-cell lymphoma, although given the rare case reports of transformation, long-term follow-up of these patients is recommended.

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Patch tests help to confirm the aetiology of the cutaneous adverse drug reactions involving delayed hypersensitivity mechanisms, but the results vary with the pattern of skin reaction and the culprit drug.

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Antimicrobial susceptibility patterns across US pediatric healthcare institutions are unknown. A national pooled pediatric antibiogram (1) identifies nationwide trends in antimicrobial resistance, (2) allows across-hospital benchmarking, and (3) provides guidance for empirical antimicrobial regimens for institutions unable to generate pediatric antibiograms.

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Eight hundred and fifty-one isolates of Staphylococci spp. were recovered from various clinical specimens. All the Staphylococcal spp. were identified by conventional microbiological methods including colony morphology, Gram stain, catalase, slide coagulase and tube coagulase. Antibiotic susceptibility testing was performed by Kirby Bauer disc diffusion method. Erythromycin-resistant isolates were examined for inducible clindamycin resistance (iMLS B ) by using double disk approximation test (D-test) at 15 mm disk separation.

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The median age of the children with GAS pleural empyema was 2 (range 0.1-7.6) years. Eighteen children (36%) had at least one risk factor for invasive GAS infection (corticosteroid use and/or current varicella). On admission, 37 patients (74%) had signs of circulatory failure, and 31 (62%) had a rash. GAS was isolated from 49/50 pleural fluid samples and from one blood culture. The commonest GAS genotype was emm1 (n=17/22). Two children died (4%). Children with GAS empyema presented more frequently with a rash (p<0.01), signs of circulatory failure (p=0.01) and respiratory disorders (p=0.02) and with low leucocyte levels (p=0.04) than children with pneumococcal empyema. Intensive care unit admissions (p<0.01), drainage procedures (p=0.04) and short-term complications (p=0.01) were also more frequent in patients with GAS empyema.

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klindan syrup 2016-05-05

There are increasing numbers of reports of community-acquired Staphylococcus aureus being resistant to methicillin. The present study was undertaken as no such reports are available for the developing nations. In a prospective study, between June to December 2001, at the Karnataka Institute of Medical Sciences, Hubli, Karnataka, India, methicillin-resistant S. aureus (MRSA) isolates were tested for clindamycin-susceptibility, a surrogate marker for community-acquired strains. Patients with clindamycin-susceptible isolates were interviewed to determine if they had acquired them in the community and also to identify any risk factors. Of the 116 patients with S. aureus infection, 18.1% had infection with methicillin-resistant strains. Clindamycin-susceptible MRSA accounted for 61.9% of cases. Among these, 46.1% patients were confirmed to have acquired the MRSA from the community, based on inclusion criteria. The community-acquired MRSA were susceptible to multiple antibiotics, as compared to nosocomial Cefuroxime Axetil 500 Mg Tablet isolates. Except for one patient with diabetes mellitus, no other patient had any known risk factor for acquiring MRSA. As significant numbers of MRSA infections are being acquired from the community, treatment options for S. aureus infections may need to be reviewed. Effective infection control programs for the community should be considered to prevent the spread of these infections.

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A prospective study was conducted at ESI-PGIMSR and ESIC Medical College, Joka, a tertiary care teaching hospital in Eastern India for Macrozit G 500 Mg a period of four months (from 1st January 2016 to 30th April 2016). Neonates were screened for omphalitis on the basis of presence of pus and redness for inclusion. Clinical examination, Gram stain and culture of umbilical discharge, identification of organisms by biochemical tests and VITEK 2 Compact (bioMereiux Inc., France) was done. Antimicrobial susceptibility by Kirby Bauer disc diffusion method and E-strip agar diffusion method (for vancomycin and teicoplanin) were performed and interpreted according to the Clinical and Laboratory Standards Institute (CLSI) guidelines version 2015.

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The results of our study reveals Metrogyl Gel Plus Side Effects that rates of resistance to commonly prescribed antibiotics in Staphylococcus aureus clinical isolates is high. In particular, rate of methicillin resistance is alarming, prompting concern on the rational use of antibiotics and vigilant laboratory-based surveillance of resistance rates in Nepal.

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Forty-nine (75%) isolates carried the lsa (C) gene and expressed the LSAP phenotype, and 12 (18 Cipro 400 Mg Po %) carried both the lnu (B) and lsa (E) genes and expressed the LSAP phenotype. The four remaining isolates were negative for all determinants investigated.

klindan 600 mg 2017-10-19

Ceftriaxone, clindamycin and amoxicillin/clavulanic acid resistance rates were 54%, 42% and 9.6%, respectively, within the Bacteroides Fungsi Obat Zycin 500 Mg fragilis group. Despite high resistance rates to various antibiotics, retapamulin inhibited 37/52 (71%) strains of the B. fragilis group and 85/87 (98%) of the other Gram-negative bacilli at a concentration of 2 mg/L or less. All the investigated strains of Clostridium perfringens were inhibited by 1 mg/L retapamulin. Three strains of C. difficile and one strain of C. clostridioforme demonstrated decreased susceptibility to retapamulin. Based on inhibitory concentrations, retapamulin was more active than clindamycin, metronidazole and ceftriaxone against Propionibacterium acnes and anaerobic Gram-positive cocci, as all isolates were inhibited by

klindan 150 mg yan etkileri 2017-09-21

A detailed microbiological analysis was made of the antibiotic resistant coagulase-negative staphylococcal flora of facial skin of 64 untreated individuals. The flora was quantified at primary isolation using both non-selective and selective media (each containing one of seven different antibiotics). The isolates obtained were tested against 18 antibiotics for multiple resistance and biotyped to species level. The incidence of the seven primary antibiotic resistance markers among the staphylococcal flora of 64 untreated subjects was: tetracycline 87.5%, erythromycin 68.8%, fusidic acid 56.3%, trimethoprim 42.4%, chloramphenicol 25%, clindamycin 9.4% and gentamicin 4.7%. In addition, penicillin resistant staphylococci were isolated from 98% of subjects. Multiply resistant strains were carried by 62.5% of individuals, with 27.9% carrying more than 100 multiply resistant staphylococci/cm2 skin. Analysis of the frequency distributions of the size of resistant staphylococcal populations revealed considerable individual variation, with many individuals carrying greater than 10(3) resistant staphylococci/cm2 skin. Multiply resistant staphylococci usually comprised less than 10% of the total staphylococcal flora, although this often represented a large number of multiply resistant organisms. Three people carried greater than 10(4) multiply resistant staphylococci/cm2 skin. Most of the singly and multiply resistant isolates were identified as strains of Staphylococcus epidermidis, which was found to carry up to eight resistances per isolate. In contrast, S. capitis, a common resident of human facial skin, was never found to carry more than two resistances per isolate. S. aureus was rarely detected on intact facial skin and the strains were not multiply resistant. Resistance to the major antistaphylococcal antibiotics was infrequent (gentamicin, methicillin) or absent (rifampicin, vancomycin, cephalothin). It was concluded that untreated individuals carry a significant pool of singly and multiply resistant staphylococci of sufficient size to Azithromycin Dosage Chronic Sinusitis be readily disseminated by direct contact and desquamation.

klindan 600 mg 1 ampul 2016-04-17

Babesiosis is a tick-borne protozoal disease with infrequent clinical complications. We report three cases of noncardiogenic pulmonary edema in patients from Nantucket Island, MA, with a history of Lyme disease and review the clinical presentation of babesiosis and its treatment. Respiratory complications Cifran Ct Syrup in our patients, as well as in the four previously reported cases in the literature, occurred a few days after initiation of medical therapy. We hypothesize that the pathophysiology of the pulmonary edema is multifactorial, due to decreased deformability of the infected erythrocytes, increased cytoadherence of red blood cells in capillaries and venules, and a possible role of excessive production of certain cytokines, such as tumor necrosis factor and interleukin-1.